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Frequent neurological diseases associated with the restless legs syndrome.
Frequent neurological diseases associated with the restless legs syndrome.
Nervenarzt 89, 1156-1164 (2018)
Background: Restless legs syndrome (RLS) is acommon neurological disease. Studies have shown that RLS is associated with avariety of medical and neurological disorders.ObjectivesUsing the example of three associated neurological diseases, the significance for everyday therapy decisions is assessed.Material and methodsAsystematic search was carried out in PubMed for all studies with the keyword RLS in combination with polyneuropathies (PNP), Parkinson's disease (PD) and multiple sclerosis (MS) and classified according to the methodology in high, medium or low study quality.ResultsOf 16studies on RLS and MS, 10 were rated as high. The high association frequency of RLS in MS between 13.3% and 65.1% (the variability possibly originates from different methods) prevents further statements about the prevalence. Within 30studies on Parkinson's disease 17 were classified as having a high quality. In patients with Parkinson disease RLS occurs most frequently during therapy and is related to the duration of dopaminergic treatment. In patients with polyneuropathy, only 5 out of 24studies were classified as being of high quality and an increased RLS prevalence was detected for acquired polyneuropathies with heterogeneous data for hereditary forms.ConclusionThere is an increased prevalence of association with RLS for the diseases discussed. This prevalence is possibly determined by the pathophysiology of these disorders. These diseases are possibly characterized by genetic predispositions as well, which can hopefully be classified more accurately in the future.
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Publication type
Article: Journal article
Document type
Review
Keywords
Differential Diagnosis ; Comorbidities ; Multiple Sclerosis ; Parkinson's Disease ; Polyneuropathy; Sleep Behavior Disorder; Willis-ekbom Disease; Parkinsons-disease; Multiple-sclerosis; Motor Restlessness; Neuropathy; Risk; Prevalence; Meis1; Polyneuropathy
ISSN (print) / ISBN
0028-2804
e-ISSN
1433-0407
Journal
Nervenarzt, Der
Quellenangaben
Volume: 89,
Issue: 10,
Pages: 1156-1164
Publisher
Springer
Publishing Place
233 Spring St, New York, Ny 10013 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Neurogenomics (ING)