PuSH - Publication Server of Helmholtz Zentrum München: LAG-3 inhibitory receptor expression identifies immunosuppressive natural regulatory plasma cells.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Lino, A.C.* ; Dang, V.D.* ; Lampropoulou, V.* ; Welle, A.* ; Joedicke, J.* ; Pohar, J.* ; Simon, Q.* ; Thalmensi, J.* ; Baures, A.* ; Flühler, V.* ; Sakwa, I.* ; Stervbo, U.* ; Ries, S.* ; Jouneau, L.* ; Boudinot, P.* ; Tsubata, T.* ; Adachi, T.* ; Hutloff, A.* ; Dörner, T.* ; Zimber-Strobl, U. ; de Vos, A.F.* ; Dahlke, K.* ; Loh, G.* ; Korniotis, S.* ; Goosmann, C.* ; Weill, J.C.* ; Reynaud, C.A.* ; Kaufmann, S.H.E.* ; Walter, J.* ; Fillatreau, S.*

LAG-3 inhibitory receptor expression identifies immunosuppressive natural regulatory plasma cells.

Immunity 49, 120-133.e9 (2018)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Hybrid

Abstract
Metrics
Extra information

B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

19.734

4.096

108