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Novel minor HLA DR associated antigens in type 1 diabetes.
Clin. Immunol. 194, 87-91 (2018)
Type 1 diabetes is an autoimmune disease leading to insulin deficiency. Autoantibodies to beta cell proteins are already present in the asymptomatic phase of type 1 diabetes. Recent findings have suggested a number of additional minor autoantigens in patients with type 1 diabetes. We have established luciferase immunoprecipitation systems (LIPS) for anti-MTIF3, anti-PPIL2, anti-NUP50 and anti-MLH1 and analyzed samples from 500 patients with type 1 diabetes at onset of clinical disease and 200 healthy individuals who had a family history of type 1 diabetes but no evidence of beta cell autoantibodies. We show significantly higher frequencies of anti-MTIF3, anti-PPIL2 and anti-MLH1 in recent onset type 1 diabetes patients in comparison to controls. In addition, antibodies to NUP50 were associated with HLA-DRB1(star)03 and antibodies to MLH1 were associated with HLA-DRB1(star)04 genotypes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Type 1 Diabetes Mellitus ; Autoantigens ; Nup50 ; Ppil2 ; Mlh1 ; Mtif3; Pd-l1 Expression; Messenger-rnas; Autoantibodies; Identification; Pathogenesis
ISSN (print) / ISBN
1521-6616
e-ISSN
1521-7035
Journal
Clinical Immunology
Quellenangaben
Volume: 194,
Pages: 87-91
Publisher
Elsevier
Publishing Place
525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
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Peer reviewed