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Müller, D.* ; Telieps, T. ; Eugster, A.* ; Weinzierl, C. ; Jolink, M. ; Ziegler, A.-G. ; Bonifacio, E.

Novel minor HLA DR associated antigens in type 1 diabetes.

Clin. Immunol. 194, 87-91 (2018)
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Type 1 diabetes is an autoimmune disease leading to insulin deficiency. Autoantibodies to beta cell proteins are already present in the asymptomatic phase of type 1 diabetes. Recent findings have suggested a number of additional minor autoantigens in patients with type 1 diabetes. We have established luciferase immunoprecipitation systems (LIPS) for anti-MTIF3, anti-PPIL2, anti-NUP50 and anti-MLH1 and analyzed samples from 500 patients with type 1 diabetes at onset of clinical disease and 200 healthy individuals who had a family history of type 1 diabetes but no evidence of beta cell autoantibodies. We show significantly higher frequencies of anti-MTIF3, anti-PPIL2 and anti-MLH1 in recent onset type 1 diabetes patients in comparison to controls. In addition, antibodies to NUP50 were associated with HLA-DRB1(star)03 and antibodies to MLH1 were associated with HLA-DRB1(star)04 genotypes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Type 1 Diabetes Mellitus ; Autoantigens ; Nup50 ; Ppil2 ; Mlh1 ; Mtif3; Pd-l1 Expression; Messenger-rnas; Autoantibodies; Identification; Pathogenesis
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1521-6616
e-ISSN 1521-7035
Journal Clinical Immunology
Quellenangaben Volume: 194, Issue: , Pages: 87-91 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes Research (IDF)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-229
G-501900-217
G-502100-001
DOI 10.1016/j.clim.2018.07.001
WOS ID WOS:000442714000012
Scopus ID 85049862051
PubMed ID 29990590
Erfassungsdatum 2018-07-12
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