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The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cell. Mol. Immunol. 16, 791-799 (2018)
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII). Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers. Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression, respectively. Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
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7.551
1.403
20
33
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Collagen-induced Arthritis; Dendritic Cells; Monoclonal-antibody; Cutting Edge; Expression; Anti-cd3; Disease; Ccl21; Ccl19
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
1672-7681
Journal
Cellular & Molecular Immunology
Quellenangaben
Volume: 16,
Issue: 10,
Pages: 791-799
Publisher
Nature Publishing Group
Publishing Place
Macmillan Building, 4 Crinan St, London N1 9xw, England
Reviewing status
Peer reviewed
Institute(s)
CF Monoclonal Antibodies (CF-MAB)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-501760-001
WOS ID
WOS:000488287800002
Scopus ID
85049598712
Erfassungsdatum
2018-07-19