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Kunsa-Ngiem, S.* ; Sutthivaiyakit, P.* ; Lowmunkhong, P.* ; Harir, M. ; Schmitt-Kopplin, P. ; Sutthivaiyakit, S.*

Magnetic molecularly imprinted polymer prepared by microwave heating for confirmatory determination of chloramphenicol in chicken feed using high-performance liquid chromatography-tandem mass spectrometry.

J. Environ. Sci. Health B 53, 738-745 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
A magnetic molecularly imprinted polymer (MMIP) for chloramphenicol was prepared using a surface-imprinted and microwave-heating-induced polymerization method. The surfaces of the magnetic particles were first double-bond functionalized with 3-(trimethoxysilyl)propyl methacrylate (gamma-MPS), followed by the copolymerization of 4-vinyl pyridine (4-VP) and trimethylolpropane trimethacrylate (TRIM) in the presence of chloramphenicol as a template and 1,1-azobis(cyclohexane-carbonitrile) (ABCN) as an initiator in a mixture of dimethyl sulfoxide and water with microwave heating at 80 degrees C. The magnetic polymer possesses supraparamagnetic properties and was used to concentrate and cleanup chicken feed extract, followed by chromatographic separation using a Lichrospher (R) 100 RP C8 column and detection with two multi-reaction monitoring transitions at m/z 321 -> 152 and m/z 321 -> 257. The mean recoveries obtained at two spiking levels were in the range of 94.6-100% The relative intra- and inter-day standard deviations were in the range of 1.4-2.6% and 5.1-5.7%, respectively. The detection limit of the method was 0.12 mu g kg(-1). This confirmatory method was successfully applied to determine chloramphenicol in chicken feed samples.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Chicken Feed ; Chloramphenicol ; Magnetic Molecularly Imprinted Polymers ; Microwave Heating; Solid-phase Extraction; Selective Recognition; Trace Analysis; Animal Feeds; Water; Samples; Antibiotics; Enrichment; Surface; Honey
ISSN (print) / ISBN 0360-1234
e-ISSN 1532-4109
Journal Journal of Environmental Science and Health, Part B
Quellenangaben Volume: 53, Issue: 11, Pages: 738-745 Article Number: , Supplement: ,
Publisher Dekker
Publishing Place 530 Walnut Street, Ste 850, Philadelphia, Pa 19106 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit BioGeoChemistry and Analytics (BGC)