PuSH - Publication Server of Helmholtz Zentrum München: Stereotactic body radiation therapy as an alternative treatment for patients with hepatocellular carcinoma compared to sorafenib: A propensity score analysis.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Bettinger, D.* ; Pinato, D.J.* ; Schultheiss, M.* ; Sharma, R.* ; Rimassa, L.* ; Pressiani, T.* ; Burlone, M.E.* ; Pirisi, M.* ; Kudo, M.* ; Park, J.W.* ; Buettner, N.* ; Neumann-Haefelin, C.* ; Boettler, T.* ; Abbasi-Senger, N.* ; Alheit, H.* ; Baus, W.* ; Blanck, O.* ; Gerum, S.* ; Guckenberger, M.* ; Habermehl, D. ; Ostheimer, C.* ; Riesterer, O.* ; Tamihardja, J.* ; Grosu, A.-L.* ; Thimme, R.* ; Brunner, T.B.* ; Gkika, E.*

Stereotactic body radiation therapy as an alternative treatment for patients with hepatocellular carcinoma compared to sorafenib: A propensity score analysis.

Liver cancer 8, 281–294 (2018)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

Background and Aims: Stereotactic body radiation therapy (SBRT) has emerged as a safe and effective treatment for patients with hepatocellular carcinoma (HCC), but its role in patients with advanced HCC is not yet defined. In this study, we aim to assess the efficacy and safety of SBRT in comparison to sorafenib treatment in patients with advanced HCC. Methods: We included 901 patients treated with sorafenib at six tertiary centers in Europe and Asia and 122 patients treated with SBRT from 13 centers in Germany and Switzerland. Medical records were reviewed including laboratory parameters, treatment characteristics and development of adverse events. Propensity score matching was performed to adjust for differences in baseline characteristics. The primary endpoint was overall survival (OS) and progression-free survival. Results: Median OS of SBRT patients was 18.1 (10.3-25.9) months compared to 8.8 (8.2-9.5) in sorafenib patients. After adjusting for different baseline characteristics, the survival benefit for patients treated with SBRT was still preserved with a median OS of 17.0 (10.8-23.2) months compared to 9.6 (8.6-10.7) months in sorafenib patients. SBRT treatment of intrahepatic lesions in patients with extrahepatic metastases was also associated with improved OS compared to patients treated with sorafenib in the same setting (17.0 vs. 10.0 months, p = 0.012), whereas in patients with portal vein thrombosis there was no survival benefit in patients with SBRT. Conclusions: In this retrospective comparative study, SBRT showed superior efficacy in HCC patients compared to patients treated with sorafenib.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Hepatocellular Carcinoma ; Overall Survival ; Propensity Score Analysis ; Sorafenib ; Stereotactic Body Radiation Therapy; Clinical-practice Guidelines; Quality-of-life; Transarterial Chemoembolization; Liver-tumors; Phase-i; Radiotherapy; Abscopal; Outcomes; Bridge; Efficacy

ISSN (print) / ISBN 2235-1795

e-ISSN 1664-5553

Journal Liver cancer

Quellenangaben Volume: 8, Issue: 4, Pages: 281–294

Publisher Karger

Publishing Place Basel ; Freiburg

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Medicine (IRM)