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Analysis of neuropsychiatric disease-related functional neuroanatomical markers in mice.
Curr. Protoc. Mouse Biol. 8, 79-128 (2018)
A better alignment of preclinical and clinical neurobiological measures could help improve neuropsychiatric disease therapeutic development. This unit describes a compendium of hypothesis-driven neuroanatomical phenotyping strategies to be employed in genetic mouse models. Using neuropsychiatric disease-based alterations as a guide, these are histological and immunohistochemical methodologies also applied to human tissue. They include quantification assays of neurochemical-, newly born neuron- and glial-cell markers, synaptic proteins, regional volumetrics, dendritic complexity and spine number as well as an index of excitation/inhibition balance. The techniques can be implemented in isolation or to complement concordant behavioral and electrophysiological analyses. Each outcome will provide functional detail necessary to decipher underlying neural circuit abnormalities associated with a brain-related phenotype in mice. Experimental design, timing, anticipated results and potential pitfalls are discussed. © 2018 by John Wiley & Sons, Inc.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Neuroanatomy ; Neurogenesis ; Neuroinflammation ; Neuronal Morphology ; Neuropsychiatric Disease ; Neurotransmitter Markers ; Synaptic Proteins
ISSN (print) / ISBN
2161-2617
Quellenangaben
Volume: 8,
Issue: 1,
Pages: 79-128
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)