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Schmitzer, M.* ; Winter, H.* ; Kneidinger, N.* ; Meimarakis, G.* ; Dick, A.* ; Schramm, R.* ; Klotz, L.V. ; Preissler, G.* ; Strobl, N.* ; von Dossow, V.* ; Schneider, C.* ; Weig, T.* ; Hatz, R.* ; Kauke, T.*

Persistence of de novo donor-specific HLA-antibodies after lung transplantation: A potential marker of decreased patient survival.

HLA 92, 24-32 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The impact of de novo donor-specific anti-HLA-antibodies (donor-specific antibody [DSA]) on outcomes in lung transplantation is still a matter of debate. We hypothesize that differentiating DSA by persistent and transient appearance may offer an additional risk assessment. The clinical relevance of HLA-antibodies was investigated prospectively in 72 recipients with a median follow-up period of 21 months. The presence of HLA-antibodies was analysed by a single antigen bead assay before and after (3 weeks, 3, 6, 12 and 18 months) transplantation. In 23 patients (32%), de novo DSAs were detected. In 10 of these patients (44%), DSA persisted throughout the follow-up period, whereas 13 of these patients (56%) had transient DSA. There was a trend towards lower 1-year-survival in DSA-positive compared with DSA-negative patients (83% vs 94%; P = 0.199). Remarkably, patients with persistent DSA had significantly reduced survival (1-year survival 60%) compared with both patients without DSA and those with transient DSA (P = 0.005). Persistent DSA represented as an independent prognostic factor for reduced overall survival in multivariate analysis (HR 8.3, 95% CI 1.8-37.0; P = 0.006). Persistence of DSA during the first year after transplantation seems to be more harmful for lung allograft function than transiently detected DSA at an early stage.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dsa ; Graft Survival ; Hla-antibodies ; Lung Transplantation; Bronchiolitis Obliterans Syndrome; International Society; Mediated Rejection; Heart; Risk; Impact
ISSN (print) / ISBN 2059-2302
e-ISSN 2059-2310
Journal HLA : immune response genetics
Quellenangaben Volume: 92, Issue: 1, Pages: 24-32 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Oxford, UK
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)