PuSH - Publication Server of Helmholtz Zentrum München: Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Nikolakopoulou, P.* ; Chatzigeorgiou, A.* ; Kourtzelis, I.* ; Toutouna, L.* ; Masjkur, J.* ; Arps-Forker, C.* ; Poser, S.W.* ; Rozman, J. ; Rathkolb, B. ; Aguilar-Pimentel, J.A. ; German Mouse Clinic Consortium* ; Wolf, E.* ; Klingenspor, M.* ; Ollert, M.* ; Schmidt-Weber, C.B. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Tsata, V.* ; Sebastian Monasor, L.* ; Troullinaki, M.* ; Witt, A.* ; Anastasiou, V. ; Chrousos, G.* ; Yi, C.-X.* ; García-Cáceres, C. ; Tschöp, M.H. ; Bornstein, S.R.* ; Androutsellis-Theotokis, A.* ; German Mouse Clinic Consortium (Garrett, L. ; Hölter, S.M. ; Zimprich, A. ; Wurst, W. ; Amarie, O.V. ; Graw, J. ; Neff, F.)

Streptozotocin-induced beta-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Sci. Rep. 8:11335 (2018)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes affects the brain. In addition to the direct effects of insulin on the brain, diabetes may also impact the brain through modulation of the inflammatory system. Here we investigate how perturbation of circulating insulin levels affects the expression of Hes3, a transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. Our data show that streptozotocin-induced beta-cell damage, high fat diet, as well as metformin, a common type 2 diabetes medication, regulate Hes3 levels in the brain. This work suggests that Hes3 is a valuable biomarker helping to monitor the state of endogenous neural stem and progenitor cells in the context of diabetes mellitus.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Migration Inhibitory Factor; Growth-factor Expression; Neural Stem-cells; Alzheimers-disease; Cognitive Impairment; Signaling Pathway; Diabetic-patients; Gene-expression; Animal-models; Factor Mif

ISSN (print) / ISBN 2045-2322

e-ISSN 2045-2322

Journal Scientific Reports

Quellenangaben Volume: 8, Issue: 1, Article Number: 11335

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Experimental Genetics (IEG)
Institute for Allergy Research (IAF)
Institute for Pancreatic Beta Cell Research (IPI)
Institute of Diabetes and Obesity (IDO)
Institute of Developmental Genetics (IDG)