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van Setten, J.* ; Brody, J.A.* ; Jamshidi, Y.* ; Swenson, B.R.* ; Butler, A.M.* ; Campbell, H.* ; del Greco, F.M.* ; Evans, D.S.* ; Gibson, Q.* ; Gudbjartsson, D.F.* ; Kerr, K.F.* ; Krijthe, B.P.* ; Lyytikäinen, L.-P.* ; Müller, C.* ; Müller-Nurasyid, M. ; Nolte, I.M.* ; Padmanabhan, S.* ; Ritchie, M.D.* ; Robino, A.* ; Smith, A.V.* ; Steri, M.* ; Tanaka, T.* ; Teumer, A.* ; Trompet, S.* ; Ulivi, S.* ; Verweij, N.* ; Yin, X.* ; Arnar, D.O.* ; Asselbergs, F.W.* ; Bader, J.S.* ; Barnard, J.* ; Bis, J.C.* ; Blankenberg, S.* ; Boerwinkle, E.* ; Bradford, Y.* ; Buckley, B.M.* ; Chung, M.K.* ; Crawford, D.C.* ; den Hoed, M.* ; Denny, J.C.* ; Dominiczak, A.F.* ; Ehret, G.B.* ; Eijgelsheim, M.* ; Ellinor, P.T.* ; Felix, S.B.* ; Franco, O.H.* ; Franke, L.* ; Harris, T.B.* ; Holm, H.* ; Ilaria, G.* ; Iorio, A.* ; Kähönen, M.* ; Kolcic, I.* ; Kors, J.A.* ; Lakatta, E.G.* ; Launer, L.J.* ; Lin, H.* ; Lin, H.J.* ; Loos, R.J.F.* ; Lubitz, S.A.* ; Macfarlane, P.W.* ; Magnani, J.W.* ; Leach, I.M.* ; Meitinger, T. ; Mitchell, B.D.* ; Münzel, T.* ; Papanicolau, G.J.* ; Peters, A. ; Pfeufer, A.* ; Pramstaller, P.P.* ; Raitakari, O.T.* ; Rotter, J.I.* ; Rudan, I.* ; Samani, N.J.* ; Schlessinger, D.* ; Silva Aldana, C.T.* ; Sinner, M.F.* ; Smith, J.D.* ; Snieder, H.* ; Soliman, E.Z.* ; Spector, T.D.* ; Stott, D.J.* ; Strauch, K. ; Tarasov, K.V.* ; Thorsteinsdottir, U.* ; Uitterlinden, A.G.* ; van Wagoner, D.R.* ; Völker, U.* ; Völzke, H.* ; Waldenberger, M. ; Jan Westra, H.* ; Wild, P.S.* ; Zeller, T.* ; Alonso, A.* ; Avery, C.L.* ; Bandinelli, S.* ; Benjamin, E.J.* ; Cucca, F.* ; Dörr, M.* ; Ferrucci, L.* ; Gasparini, P.* ; Gudnason, V.* ; Hayward, C.* ; Heckbert, S.R.* ; Hicks, A.A.* ; Jukema, J.W.* ; Kääb, S.* ; Lehtimäki, T.* ; Liu, Y.* ; Munroe, P.B.* ; Parsa, A.* ; Polasek, O.* ; Psaty, B.M.* ; Roden, D.M.* ; Schnabel, R.B.* ; Sinagra, G.* ; Stefansson, K.* ; Stricker, B.H.* ; van der Harst, P.* ; van Duijn, C.M.* ; Wilson, J.F.* ; Gharib, S.A.* ; de Bakker, P.I.W.* ; Isaacs, A.* ; Arking, D.E.* ; Sotoodehnia, N.*

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Nat. Commun. 9:2904 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of ~105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ion-channel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 9, Issue: 1, Pages: , Article Number: 2904 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-500700-001
G-504000-001
G-504091-001
DOI 10.1038/s41467-018-04766-9
Scopus ID 85050692238
PubMed ID 30046033
Erfassungsdatum 2018-07-30
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