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Nimble and ready to mingle: Transposon outbursts of early development.
Trends Genet. 34, 806-820 (2018)
Transposable elements are the largest individual constituent of mammalian genomes. These elements are highly diverse, a consequence of the multiplicity of genomic habitats that they inhabit and of the complex evolutionary histories that they have developed therein. Intriguingly, a surge of transposable element transcription occurs during mammalian preimplantation development, contributing to the establishment of totipotency and pluripotency and to the activation of the embryonic genome. However, it remains an open question how such an evolutionarily divergent set can mediate such conserved developmental processes. Here, we review transposable element diversity across mammals and their evolutionary significance. We also discuss the implications that their high evolutionary divergence has for the regulation of preimplantation development across mammals.
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10.556
2.025
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Publication type
Article: Journal article
Document type
Review
Keywords
Cellular Plasticity ; Evolutionary Genomics ; Genome Architecture ; Pluripotency ; Totipotency ; Transposons; Bat Myotis-lucifugus; Rolling-circle Transposons; Endogenous Retroviruses; Preimplantation Embryos; Placental Mammals; Dna Transposons; Evolutionary Dynamics; Eukaryotic Genomes; Line-1 Activity; Ribosomal-rna
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
0168-9479
Journal
Trends in Genetics
Quellenangaben
Volume: 34,
Issue: 10,
Pages: 806-820
Publisher
Elsevier
Publishing Place
84 Theobalds Rd, London Wc1x 8rr, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-506200-001
WOS ID
WOS:000445026600007
Scopus ID
85050397344
PubMed ID
30057183
Erfassungsdatum
2018-08-01