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Lee, J.J.* ; Wedow, R.* ; Okbay, A.* ; Kong, E.* ; Maghzian, O.* ; Zacher, M.* ; Nguyen-Viet, T.A.* ; Bowers, P.* ; Sidorenko, J.* ; Karlsson Linnér, R.* ; Fontana, M.A.* ; Kundu, T.* ; Lee, C.* ; Li, H.* ; Li, R.* ; Royer, R.* ; Timshel, P.N.* ; Walters, R.K.* ; Willoughby, E.A.* ; Yengo, L.* ; Agee, M.* ; Alipanahi, B.* ; Auton, A.* ; Bell, R.K.* ; Bryc, K.* ; Elson, S.L.* ; Fontanillas, P.* ; Hinds, D.A.* ; McCreight, J.C.* ; Huber, K.E.* ; Litterman, N.K.* ; McIntyre, M.H.* ; Mountain, J.L.* ; Noblin, E.S.* ; Northover, C.A.M.* ; Pitts, S.J.* ; Sathirapongsasuti, J.F.* ; Sazonova, O.V.* ; Shelton, J.F.* ; Shringarpure, S.* ; Tian, C.* ; Vacic, V.* ; Wilson, C.H.* ; Beauchamp, J.P.* ; Pers, T.H.* ; Rietveld, C.A.* ; Turley, P.* ; Chen, G.B.* ; Emilsson, V.* ; Meddens, S.F.W.* ; Oskarsson, S.* ; Pickrell, J.K.* ; Social Science Genetic Association Consortium (Lichtner, P. ; Meitinger, T. ; Gieger, C. ; Baumbach, C. ; Strauch, K. ; Meisinger, C.) ; Abdellaoui, A.* ; Ahluwalia, T.S.* ; Bacelis, J.* ; Bjornsdottir, G.* ; Brandsma, J.H.* ; Concas, M.P.* ; Derringer, J.* ; Furlotte, N.A.* ; Galesloot, T.E.* ; Girotto, G.* ; Gupta, R.* ; Hall, L.M.* ; Harris, S.E.* ; Hofer, E.* ; Visscher, P.M.* ; Benjamin, D.J.* ; Cesarini, D.*

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Nat. Genet. 52, 1112-1121 (2018)
Postprint DOI PMC
Open Access Green
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 52, Issue: , Pages: 1112-1121 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CF Genomics (CF-GEN)
Institute of Human Genetics (IHG)
Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)
Independent Research Group Clinical Epidemiology (KEPI)