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De Santis, M. ; Bolukbas, D.A.* ; Lindstedt, S.* ; Wagner, D.E.

How to build a lung: Latest advances and emerging themes in lung bioengineering.

Eur. Respir. J. 52:1601355 (2018)
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Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.
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Publication type Article: Journal article
Document type Review
Keywords Pluripotent Stem-cells; Ex-vivo; Extracellular-matrix; In-vitro; Epithelial-cells; High-throughput; Comparative Decellularization; Immunosuppressive Therapy; Efficient Derivation; Rotating Bioreactor
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 52, Issue: 1, Pages: , Article Number: 1601355 Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-503100-001
DOI 10.1183/13993003.01355-2016
WOS ID WOS:000440846300003
Scopus ID 85054584068
Erfassungsdatum 2018-09-07
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