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A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses.
J. Biol. Chem. 285, 26223-26232 (2010)
Proteins of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing family recently gained attention as important components of the innate immune system. Although over 20 of these proteins are present in humans, only a few members including the cytosolic pattern recognition receptors NOD1, NOD2, and NLRP3 have been analyzed extensively. These NLRs were shown to be pivotal for mounting innate immune response toward microbial invasion. Here we report on the characterization of human NLRC5 and provide evidence that this NLR has a function in innate immune responses. We found that NLRC5 is a cytosolic protein expressed predominantly in hematopoetic cells. NLRC5 mRNA and protein expression was inducible by the double-stranded RNA analog poly(I.C) and Sendai virus. Overexpression of NLRC5 failed to trigger inflammatory responses such as the NF-kappaB or interferon pathways in HEK293T cells. However, knockdown of endogenous NLRC5 reduced Sendai virus- and poly(I.C)-mediated type I interferon pathway-dependent responses in THP-1 cells and human primary dermal fibroblasts. Taken together, this defines a function for NLRC5 in anti-viral innate immune responses.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
NF-Kappa-B; Double-Stranded-RNA; Pattern-recognition; Signaling pathways; Immune-responses; Epithelial-cells; Viral-infection; Innate immunity; Activation; Gene
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
0021-9258
e-ISSN
1083-351X
Quellenangaben
Volume: 285,
Issue: 34,
Pages: 26223-26232
Publisher
American Society for Biochemistry and Molecular Biology
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)
PSP Element(s)
G-501700-003
PubMed ID
20538593
Scopus ID
77956220440
Erfassungsdatum
2010-10-14