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Luijk, R.* ; Wu, H.* ; Ward-Caviness, C.K. ; Hannon, E.* ; Carnero-Montoro, E.* ; Min, J.L.* ; Mandaviya, P.R.* ; Müller-Nurasyid, M. ; Mei, H.* ; van der Maarel, S.M.* ; BIOS Consortium* ; Relton, C.* ; Mill, J.* ; Waldenberger, M. ; Bell, J.T.* ; Jansen, R.* ; Zhernakova, A.* ; Franke, L.* ; 't Hoen, P.A.C.* ; Boomsma, D.I.* ; van Duijn, C.M.* ; Van Greevenbroek, M.M.J.* ; Veldink, J.H.* ; Wijmenga, C.* ; van Meurs, J.B.* ; Daxinger, L.* ; Slagboom, P.E.* ; van Zwet, E.W.* ; Heijmans, B.T.*

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation.

Nat. Commun. 9:3738 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, similar to 10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a discovery data-set of 1867 females and 1398 males and a replication sample of 3351 females, we show that genetic variation at three autosomal loci is associated with female-specific changes in X-chromosome methylation. Through cis-eQTL expression analysis, we map these loci to the genes SMCHD1/METTL4, TRIM6/HBG2, and ZSCAN9. Low-expression alleles of the loci are predominantly associated with mild hypomethylation of CpG islands near genes known to variably escape XCI, implicating the autosomal genes in variable XCI. Together, these results suggest a genetic basis for variable escape from XCI and highlight the potential of a population genomics approach to identify genes involved in XCI.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Human Genome; Linked Gene; Histone H3; Expression; Smchd1; Variability; Objectives; Epigenomes; Rotterdam; Clusters
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 9, Issue: 1, Pages: , Article Number: 3738 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504100-001
G-504091-001
DOI 10.1038/s41467-018-05714-3
WOS ID WOS:000444554000001
Scopus ID 85053315812
PubMed ID 30218040
Erfassungsdatum 2018-09-24
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