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Rodriguez-Calvo, T.

Enteroviral infections as a trigger for type 1 diabetes.

Curr. Diab. Rep. 18:106 (2018)
Postprint DOI PMC
Open Access Green
Purpose of ReviewTo provide an overview of studies that have detected enteroviruses (EV) in samples from people with type 1 diabetes (T1D), the techniques they have used, and which challenges they have encountered.Recent FindingsRecent studies have detected EVs in serum, blood, stools, nasal swabs, and pancreas of people with T1D before or around clinical onset of disease, indicating that an association between EV infections and T1D exists. However, definitive evidence for its role as disease triggers is lacking. Recent access to human samples is starting to provide the necessary tools to define their role in disease pathogenesis. Emerging evidence suggests that chronic infections take place in the pancreas of diabetic donors. However, the development of sensitive techniques able to detect low amounts of viral protein and RNA still constitute a major challenge for the field.SummaryNew evidence at the protein, RNA, and host immune response level suggests a role for EV infections in the development of autoimmunity. In the upcoming years, new technologies, collaborative efforts, and therapeutic interventions are likely to find a definitive answer for their role in disease pathogenesis.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Enteroviruses ; Type 1 Diabetes ; Ifn-response ; Viral Protein ; Viral Rna; Early-childhood Infections; Beta-cell Autoimmunity; Islet Autoimmunity; Respiratory-infections; Coxsackievirus B1; Pancreatic-islets; Alpha-interferon; Young Daisy; Early-life; Children
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Journal Current Diabetes Reports
Quellenangaben Volume: 18, Issue: 11, Pages: , Article Number: 106 Supplement: ,
Publisher Springer
Publishing Place Heidelberg [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)