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Gerlini, R. ; Berti, L. ; Darr, J. ; Lassi, M. ; Brandmaier, S. ; Fritsche, L. ; Scheid, F. ; Böhm, A. ; Königsrainer, A.* ; Grallert, H. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Staiger, H. ; Teperino, R.

Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.

Mol. Metab. 18, 42-50 (2018)
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Objective: Although debated, metabolic health characterizes 10-25% of obese individuals and reduces risk of developing life-threatening comorbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown.Methods: Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases.Results and conclusions: Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity. (C) 2018 The Authors. Published by Elsevier GmbH.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Obesity ; Glucose Tolerance ; Insulin Sensitivity ; Transcriptomics ; Mouse Genetics ; Systemic Phenotyping; Polycomb Protein; Gene-expression; Adipose-tissue; Disease; Consortium; Pathway; Leptin
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Journal Molecular Metabolism
Quellenangaben Volume: 18, Issue: , Pages: 42-50 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Epidemiology (EPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
30202 - Environmental Health
30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
Helmholtz Diabetes Center
PSP Element(s) G-501900-069
G-502400-001
G-504091-002
G-504091-003
G-501900-402
G-500600-001
DOI 10.1016/j.molmet.2018.09.004
WOS ID WOS:000450929200005
Scopus ID 85054434106
PubMed ID 30309776
Erfassungsdatum 2018-09-27
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