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Open Access Green as soon as Postprint is submitted to ZB.
The emerging role of EpCAM in cancer and stem cell signaling.
Cancer Res. 69, 5627-5629 (2009)
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with certain cancers. EpCAM has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
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Publication type
Article: Journal article
Document type
Review
Keywords
colorectal-carcinoma; adhesion molecule; breast-cancer; antigen epcam; ep-cam; cadherins; invasion; marker
ISSN (print) / ISBN
0008-5472
e-ISSN
1538-7445
Journal
Cancer Research
Quellenangaben
Volume: 69,
Issue: 14,
Pages: 5627-5629
Publisher
American Association for Cancer Research (AACR)
Publishing Place
Philadelphia, Pa.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Molecular Oncology (AGV-KON)