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Brankatschk, M.* ; Gutmann, T. ; Knittelfelder, O.* ; Palladini, A. ; Prince, E.* ; Grzybek, M. ; Brankatschk, B. ; Shevchenko, A.* ; Coskun, Ü. ; Eaton, S.*

A temperature-dependent switch in feeding preference improves Drosophila development and survival in the cold.

Dev. Cell 46, 781-793.e4 (2018)
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How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15 degrees C and that the different lipids present in plants improve survival at low temperatures. We show that Drosophila require dietary unsaturated fatty acids present in plants to adjust membrane fluidity and maintain motor coordination. Feeding on plants extends lifespan and survival for many months at temperatures consistent with overwintering in temperate climates. Thus, physiological alterations caused by a temperature-dependent dietary shift could help Drosophila survive seasonal temperature changes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Drosophila Melanogaster ; Foraging Behavior ; Homeoviscous Adaption ; Insulin Signaling ; Lifespan ; Lipidomics ; Membrane Fluidity ; Overwintering ; Temperature Acclimation; Fatty-acid-composition; Seasonal-changes; Membrane-lipids; Saccharomyces-cerevisiae; Overwintering Larvae; Thermal Adaptation; Shotgun Lipidomics; Cell-membranes; Na+/k+-atpase; Chill-coma
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Journal Developmental Cell
Quellenangaben Volume: 46, Issue: 6, Pages: 781-793.e4 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502600-002
DOI 10.1016/j.devcel.2018.05.028
WOS ID WOS:000445410400014
PubMed ID 30253170
Erfassungsdatum 2018-10-02
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