PuSH - Publication Server of Helmholtz Zentrum München: Blimp-1 functions as a molecular switch to prevent inflammatory activity in Foxp3<sup>+</sup> ROR gamma t<sup>+ </sup>regulatory T cells.

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Ogawa, C.* ; Bankoti, R.* ; Nguyen, T.* ; Hassanzadeh-Kiabi, N.* ; Nadeau, S.* ; Porritt, R.A.* ; Couse, M.* ; Fan, X.* ; Dhall, D.* ; Eberl, G.* ; Ohnmacht, C. ; Martins, G.A.*

Blimp-1 functions as a molecular switch to prevent inflammatory activity in Foxp3⁺ ROR gamma t⁺regulatory T cells.

Cell Rep. 25, 19-28.e5 (2018)

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Foxp3(+) regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood. Here we show that the transcription factor Blimp-1 is a crucial regulator of the Foxp3(+)ROR gamma t(+) Treg subset. The intrinsic expression of Blimp-1 in these cells is required to prevent production of Th17-associated cytokines. Direct binding of Blimp-1 to the II17 locus in Treg is associated with inhibitory histone modifications but unaltered binding of ROR gamma t. In the absence of Blimp-1, the II17 locus is activated, with increased occupancy of the co-activator p300 and abundant binding of the transcriptional regulator IRF4, which is required, along with ROR gamma t, for IL-17 expression in the absence of Blimp-1. We also show that despite their sustained expression of Foxp3, Blimp-1(-/-) ROR gamma t(+)IL-17-producing Treg lose suppressor function and can promote intestinal inflammation, indicating that repression of Th17-associated cytokines by Blimp-1 is a crucial requirement for ROR gamma t(+) Treg function.

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PuSH - Publication Server of Helmholtz Zentrum München

Blimp-1 functions as a molecular switch to prevent inflammatory activity in Foxp3+ ROR gamma t+ regulatory T cells.

Blimp-1 functions as a molecular switch to prevent inflammatory activity in Foxp3⁺ ROR gamma t⁺regulatory T cells.