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Challenges and guidelines toward 4D nucleome data and model standards.
Nat. Genet. 50, 1352-1358 (2018)
Due to recent advances in experimental and theoretical approaches, the dynamic three-dimensional organization (3D) of the nucleus has become a very active area of research in life sciences. We now understand that the linear genome is folded in ways that may modulate how genes are expressed during the basic functioning of cells. Importantly, it is now possible to build 3D models of how the genome folds within the nucleus and changes over time (4D). Because genome folding influences its function, this opens exciting new possibilities to broaden our understanding of the mechanisms that determine cell fate. However, the rapid evolution of methods and the increasing complexity of data can result in ambiguity and reproducibility challenges, which may hamper the progress of this field. Here, we describe such challenges ahead and provide guidelines to think about strategies for shared standardized validation of experimental 4D nucleome data sets and models.
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Publication type
Article: Journal article
Document type
Review
Keywords
Embryonic Stem-cells; Protein Data-bank; Chromosome Conformation Capture; Range Genomic Interactions; In-vivo; Hi-c; Multifocus Microscopy; Transcription Factors; Gene-expression; 3-dimensional Architecture
ISSN (print) / ISBN
1061-4036
e-ISSN
1546-1718
Journal
Nature Genetics
Quellenangaben
Volume: 50,
Issue: 10,
Pages: 1352-1358
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epigenetics and Stem Cells (IES)