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Blume, J.* ; Ziętara, N.* ; Witzlau, K.* ; Liu, Y.* ; Ortiz, O. ; Puchałka, J.* ; Winter, S.J.* ; Kunze-Schumacher, H.* ; Saran, N.* ; Düber, S.* ; Roy, B.* ; Weiss, S.* ; Klein, C.* ; Wurst, W. ; Łyszkiewicz, M.* ; Krueger, A.*

miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1.

Eur. J. Immunol. 49, 121-132 (2019)
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The interdependence of posttranscriptional gene regulation via miRNA and transcriptional regulatory networks in lymphocyte development is poorly understood. Here, we identified miR-191 as direct upstream modulator of a transcriptional module comprising the transcription factors Foxp1, E2A, and Egr1. Deletion as well as ectopic expression of miR-191 resulted in developmental arrest in B lineage cells, indicating that fine tuning of the combined expression levels of Foxp1, E2A, and Egr1, which in turn control somatic recombination and cytokine-driven expansion, constitutes a prerequisite for efficient B-cell development. In conclusion, we propose that miR-191 acts as a rheostat in B-cell development by fine tuning a key transcriptional program.
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Publication type Article: Journal article
Document type Scientific Article
Keywords B Cells ; Lymphocyte Development ; Mirna ; Mir-191 ; Transcriptional Factors; Gene-expression; Differentiation; Recombination; Proteins; Proliferation; Binding; Family; Growth; E47; Rna
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Journal European Journal of Immunology
Quellenangaben Volume: 49, Issue: 1, Pages: 121-132 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
DOI 10.1002/eji.201847660
WOS ID WOS:000455030800012
Scopus ID 85055250220
PubMed ID 30281154
Erfassungsdatum 2018-10-19
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