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A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.
Parkinsonism Relat. Disord. 60, 43-45 (2019)
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical 'and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Parkinson's Disease ; Intestinal Inflammation ; Short Chain Fatty Acids ; Inflammatory Bowel Disease ; Calprotectin ; Nod2 ; Crohn's Disease; Chain Fatty-acids; Bowel-disease; Microbiota; Vagotomy
ISSN (print) / ISBN
1353-8020
e-ISSN
1873-5126
Journal
Parkinsonism & Related Disorders
Quellenangaben
Volume: 60,
Pages: 43-45
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Neurogenomics (ING)