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Becker, A.* ; Faßbender, K.* ; Oertel, W.H. ; Unger, M.M.*

A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.

Parkinsonism Relat. Disord. 60, 43-45 (2019)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical 'and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Parkinson's Disease ; Intestinal Inflammation ; Short Chain Fatty Acids ; Inflammatory Bowel Disease ; Calprotectin ; Nod2 ; Crohn's Disease; Chain Fatty-acids; Bowel-disease; Microbiota; Vagotomy
Language
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1353-8020
e-ISSN 1873-5126
Quellenangaben Volume: 60, Issue: , Pages: 43-45 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503200-001
PubMed ID 30292735
Erfassungsdatum 2018-10-22