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Ovsepian, S.V. ; O’Leary, V.B.*

Can arginase inhibitors be the answer to therapeutic challenges in Alzheimer's disease?

Neurotherapeutics 15, 1032-1035 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
While the extensive hunt for therapeutics combating Alzheimer's disease (AD) has fallen short of delivering effective treatments, breakthroughs towards understanding the disease mechanisms and identifying areas for future research have nevertheless been enabled. The majority of clinical trials with beta- and gamma-secretase modulators have been suspended from additional studies or terminated due to toxicity issues and health concerns. The lack of progress in developing innovative AD therapies has also prompted a resurgence of interest in more traditional symptomatic treatments with cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists, as well as in the research of immune response modulators. Recently, evidence has emerged showing that inhibitors of arginine metabolism and in particular blockers of arginase, an enzyme that catalyzes the breakdown of L-arginine, could present an effective therapeutic candidate for halting the progression of AD and boosting cognition and memory. In this commentary, we present a brief overview of reports on arginase inhibitors in AD mouse models and discuss emerging advantages and areas for careful consideration on the road to clinical translation.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords L-norvaline ; Arginine Metabolism ; Nitric Oxide ; Amyloid Beta ; Cognitive Enhancers ; Alzheimer's Disease; Triple-transgenic Model; Amyloid-beta; Secretase Inhibitors; Arginine Metabolism; Difluoromethylornithine; Oligomers; Lessons; Enzyme; Muscle; Trial
ISSN (print) / ISBN 1933-7213
e-ISSN 1878-7479
Journal Neurotherapeutics
Quellenangaben Volume: 15, Issue: 4, Pages: 1032-1035 Article Number: , Supplement: ,
Publisher Springer
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)