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Asymmetric cell division with stochastic growth rate. Dedicated to the memory of the late Spartak Agamirzayev.
Math. Meth. Appl. Sci. 41, 8059-8069 (2018)
A cell growth model for a size-structured cell population with a stochastic growth rate for size and division into two daughter cells of unequal size is studied in this paper. The model entails an initial boundary value problem that involves a second-order parabolic partial differential equation with two nonlocal terms, the presence of which is a consequence of asymmetry in the cell division. The solution techniques for solving such problems are rare due to the nonlocal terms. In this paper, we solve the initial boundary value problem for arbitrary initial distributions. We obtain a separable solution, as well as the general solution to the partial differential equation, and show that the solutions converge to the separable solution for large time. As in the symmetric division case, the dispersion term does not affect the rate of convergence to the separable solution.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
0170-4214
e-ISSN
1099-1476
Quellenangaben
Volume: 41,
Issue: 17,
Pages: 8059-8069
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-503800-001
DOI
10.1002/mma.5269
Scopus ID
85062599368
Scopus ID
85053504379
Erfassungsdatum
2018-10-18