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Open Access Green as soon as Postprint is submitted to ZB.
Periaortic adipose tissue compared with peribrachial adipose tissue mass as markers and possible modulators of cardiometabolic risk.
Angiology 69, 854-860 (2018)
Increased perivascular fat mass contributes to cardiometabolic risk (CMR). High peribrachial adipose tissue (PBAT) associates with insulin resistance independently of established CMR parameters. It is unknown to what extent periaortic adipose tissue (PAAT) may have a similar impact. In 95 participants, precise quantification of total adipose tissue, PBAT, PAAT, visceral adipose tissue (VAT), and liver fat (LF) content was performed by whole-body magnetic resonance imaging. Insulin sensitivity was determined by oral glucose tolerance test and carotid intima-media thickness (cIMT) by high-resolution ultrasound. In univariate analyses, PAAT correlated with PBAT (beta = .65, P < .0001). A negative correlation of PAAT (beta = -.35, P = .0002) and PBAT (beta = -.43, P < .0001) with insulin sensitivity was observed. While in a stepwise forward regression analysis the relationship of PAAT with insulin sensitivity was no longer significant after adjustment for VAT, LF content, and other CMR factors (P = 0.42), PBAT still correlated with insulin sensitivity (r(2) = .35, P = .01). The association between PAAT and cIMT (beta = .49, P < .0001) remained significant after adjustment for these variables (r(2) = .42, P = .0001). Although PAAT and PBAT strongly correlate, PAAT is not associated with insulin resistance, but with cIMT. Therefore, PAAT and PBAT may act differently as possible modulators of insulin resistance and subclinical atherosclerosis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Perivascular Adipose Tissue ; Intima-media Thickness ; Insulin Resistance ; Arteriosclerosis ; Cardiometabolic Risk; Intima-media Thickness; Cardiovascular-disease; Insulin-resistance; Abdominal Obesity; Metabolically Benign; Vascular-disease; Heart-disease; Fatty Liver; Events; Artery
ISSN (print) / ISBN
0003-3197
e-ISSN
1940-1574
Journal
Angiology
Quellenangaben
Volume: 69,
Issue: 10,
Pages: 854-860
Publisher
Sage
Publishing Place
2455 Teller Rd, Thousand Oaks, Ca 91320 Usa
Non-patent literature
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Reviewing status
Peer reviewed