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Weigert, C. ; Hoene, M.* ; Plomgaard, P.*

Hepatokinesa novel group of exercise factors.

Pflugers Arch. 471, 383-396 (2018)
Postprint DOI PMC
Open Access Green
Regular physical activity not only improves the exercise capacity of the skeletal muscle performing the contractions, butit is beneficial for the whole body. An extensive search for exercise factors mediating these beneficial effects has been going on for decades. Particularly skeletal muscle tissue has been investigated as a source of circulating exercise factors, and several myokines have been identified. However, exercise also has an impact on other tissues. The liver is interposed between energy storing and energy utilising tissues and is highly active during exercise, maintaining energy homeostasis. Recently, a novel group of exercise factorstermed hepatokineshas emerged. These proteins (fibroblast growth factor 21, follistatin, angiopoietin-like protein 4, heat shock protein 72, insulin-like growth factor binding protein 1) are released from the liver and increased in the bloodstream during or in the recovery after an exercise bout. In this narrative review, we evaluate this new group of exercise factors focusing on the regulation and potential function in exercise metabolism and adaptations. These hepatokines may convey some of the beneficial whole-body effects of exercise that could ameliorate metabolic diseases, such as obesity or type 2 diabetes.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Hepatokines ; Liver ; Exercise ; Training ; Energy Metabolism ; Insulin Resistance ; Type 2 Diabetes ; Fgf21 ; Angptl4 ; Follistatin ; Selenoprotein P ; Hsp72 ; Igfbp; Growth-factor 21; Angiopoietin-like Protein-4; Hepatic Glucose-production; Human Skeletal-muscle; Free Fatty-acids; Selenoprotein P; Ppar-alpha; Heat-shock; Follistatin Concentrations; Transgenic Overexpression
ISSN (print) / ISBN 0031-6768
e-ISSN 1432-2013
Journal Pflügers Archiv
Quellenangaben Volume: 471, Issue: 3, Pages: 383-396 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)