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Kachuri, L.* ; Saarela, O.* ; Bojesen, S.E.* ; Davey Smith, G.* ; Liu, G.* ; Landi, M.T.* ; Caporaso, N.E.* ; Christiani, D.C.* ; Johansson, M.* ; Panico, S.* ; Overvad, K.* ; Trichopoulou, A.* ; Vineis, P.* ; Scelo, G.* ; Zaridze, D.* ; Wu, X.* ; Albanes, D.* ; Diergaarde, B.* ; Lagiou, P.* ; Macfarlane, G.J.* ; Aldrich, M.C.* ; Tardón, A.* ; Rennert, G.* ; Olshan, A.F.* ; Weissler, M.C.* ; Chen, C.* ; Goodman, G.E.* ; Doherty, J.A.* ; Ness, A.R.* ; Bickeböller, H.* ; Wichmann, H.-E. ; Risch, A.* ; Field, J.K.* ; Teare, M.D.* ; Kiemeney, L.A.* ; van der Heijden, E.H.F.M.* ; Carroll, J.C.* ; Haugen, A.* ; Zienolddiny, S.* ; Skaug, V.* ; Wünsch-Filho, V.* ; Tajara, E.H.* ; Ayoub Moysés, R.* ; Daumas Nunes, F.* ; Lam, S.* ; Eluf-Neto, J.* ; Lacko, M.* ; Peters, W.H.M.* ; Le Marchand, L.* ; Duell, E.J.* ; Andrew, A.S.* ; Franceschi, S.* ; Schabath, M.B.* ; Manjer, J.* ; Arnold, S.J.* ; Lazarus, P.* ; Mukeriya, A.* ; Swiatkowska, B.* ; Janout, V.* ; Holcatova, I.* ; Stojsic, J.* ; Mates, D.* ; Lissowska, J.* ; Boccia, S.* ; Lesseur, C.* ; Zong, X.* ; McKay, J.D.* ; Brennan, P.* ; Amos, C.I.* ; Hung, R.J.*

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers.

Int. J. Epidemiol. 48, 751-766 (2018)
Publ. Version/Full Text Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mendelian Randomization (MR) and mediation analyses.Methods: We developed a novel genetic instrument for TL in chromosome 5p15.33, using variants identified through deep-sequencing, that were genotyped in 2051 cancer-free subjects. Next, we conducted an MR analysis of lung (16 396 cases, 13 013 controls) and head and neck cancer (4415 cases, 5013 controls) using eight genetic instruments for TL. Lastly, the 5p15.33 instrument and distinct 5p15.33 lung cancer risk loci were evaluated using two-sample mediation analysis, to quantify their direct and indirect, telomere-mediated, effects.Results: The multi-allelic 5p15.33 instrument explained 1.49-2.00% of TL variation in our data (p = 2.6 x 10(-9)). The MR analysis estimated that a 1000 base-pair increase in TL increases risk of lung cancer [odds ratio (OR) = 1.41, 95% confidence interval (CI): 1.20-1.65] and lung adenocarcinoma (OR = 1.92, 95% CI: 1.51-2.22), but not squamous lung carcinoma (OR = 1.04, 95% CI: 0.83-1.29) or head and neck cancers (OR = 0.90, 95% CI: 0.70-1.05). Mediation analysis of the 5p15.33 instrument indicated an absence of direct effects on lung cancer risk (OR = 1.00, 95% CI: 0.95-1.04). Analysis of distinct 5p15.33 susceptibility variants estimated that TL mediates up to 40% of the observed associations with lung cancer risk.Conclusions: Our findings support a causal role for long telomeres in lung cancer aetiology, particularly for adenocarcinoma, and demonstrate that telomere maintenance partially mediates the lung cancer susceptibility conferred by 5p15.33 loci.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Lung Cancer ; Telomere Length ; Chromosome 5p15.33 ; Mendelian Randomization ; Mediation Analysis ; Tert; Genome-wide Association; Susceptibility Loci; Genetic-variants; Never Smokers; Dysfunction; Identification; Epidemiology; Metaanalysis; Challenges; Extension
ISSN (print) / ISBN 0300-5771
e-ISSN 1464-3685
Journal International Journal of Epidemiology
Quellenangaben Volume: 48, Issue: 3, Pages: 751-766 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)