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Apisarnthanarax, S.* ; Bowen, S.R.* ; Combs, S.E.

Proton beam therapy and carbon ion radiotherapy for hepatocellular carcinoma.

Semin. Radiat. Oncol. 28, 309-320 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Charged particle therapy with proton beam therapy (PBT) and carbon ion radiotherapy (CIRT) has emerged as a promising radiation modality to minimize radiation hepatotoxicity while maintaining high rates of tumor local control. Both PBT and CIRT deposit the majority of their dose at the Bragg peak with little to no exit dose, resulting in superior sparing of normal liver tissue. CIRT has an additional biological advantage of increased relative biological effectiveness, which may allow for increased hypofractionation regimens. Retrospective and prospective studies have demonstrated encouragingly high rates of local control and overall survival and low rates of hepatotoxicity with PBT and CIRT. Ongoing randomized trials will evaluate the value of PBT over photons and other standard liver-directed therapies and future randomized trials are needed to assess the value of CIRT over PBT.
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Publication type Article: Journal article
Document type Review
Keywords Stereotactic Body Radiotherapy; Effectiveness Rbe Values; Radiation-therapy; Phase-ii; Transarterial Chemoembolization; Liver Toxicity; Porta-hepatis; Irradiation; Cirrhosis; Model
Language english
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1053-4296
e-ISSN 1532-9461
Journal Seminars in Radiation Oncology
Quellenangaben Volume: 28, Issue: 4, Pages: 309-320 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, Pa 19103-2899 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
DOI 10.1016/j.semradonc.2018.06.008
WOS ID WOS:000448490600006
Scopus ID 85051734933
PubMed ID 30309641
Erfassungsdatum 2018-11-16
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