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Kovács-Nagy, R.* ; Morin, G.* ; Al Nouri, M.* ; Brandau, O.* ; Saadi, N.W.* ; Nouri, M.A.* ; van den Broek, F.* ; Prokisch, H. ; Mayr, J.A.* ; Wortmann, S.B.

HTRA2 defect: A recognizable inborn error of metabolism with 3-methylglutaconic aciduria as discriminating feature characterized by neonatal movement disorder and epilepsy-report of 11 patients.

Neuropediatrics 49, 373-378 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Neonatal-onset movement disorders, especially in combination with seizures, are rare and often related to mitochondrial disorders. 3-methylglutaconic aciduria (3-MGA-uria) is a marker for mitochondria) dysfunction. In particular, consistently elevated urinary excretion of 3-methylglutaconic acid is the hallmark of a small but growing group of inborn errors of metabolism (IEM) due to defective phospholipid remodeling or mitochondrial membrane-associated disorders (mutations in TAZ, SERAC1, OPA3, CLPB, DNAJC19, TMEM70, TIMM50). Exome/genome sequencing is a powerful tool for the diagnosis of the clinically and genetically heterogeneous mitochondrial disorders. Here, we report 11 individuals, of whom 2 are previously unpublished, with biallelic variants in high temperature requirement protein A2 (HTRA2) encoding a mitochondria-localized serine protease. All individuals presented a recognizable phenotype with neonatal- or infantile-onset neurodegeneration and death within the first month of life. Hallmark features were central hypopnea/apnea leading to respiratory insufficiency, seizures, neutropenia, 3-MGA-uria, tonus dysregulation, and dysphagia. Tremor, jitteriness, dystonia, and/or clonus were also common. HTRA2 defect should be grouped under the IEM with 3-MGA-uria as discriminating feature. Clinical characteristics overlap with other disorders of this group suggesting a common underlying pathomechanism. Urinary organic acid analysis is a noninvasive and inexpensive test that can guide further genetic testing in children with suggestive clinical findings.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mitochondrial Dysfunction ; Developmental Delay ; Respiratory Insufficiency ; Dystonia ; Tremor; Serine-protease Htra2/omi; Parkinsons-disease; Essential Tremor; Mutations; Deficiency; Omi/htra2; P.g399s; Mice
ISSN (print) / ISBN 0174-304X
e-ISSN 1439-1899
Journal Neuropediatrics
Quellenangaben Volume: 49, Issue: 6, Pages: 373-378 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Rudigerstr 14, D-70469 Stuttgart, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)