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Open Access Green as soon as Postprint is submitted to ZB.
Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia.
Adv. Exp. Med. Biol. 1100, 127-139 (2018)
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Early response to therapy, especially the measurement of minimal residual disease (MRD), remains the most reliable and strongest independent prognostic parameter. Intriguingly, little is known on the mechanisms sustaining MRD in that disease. Here, we summarize existing evidence on the influences of molecular genetics and clonal architecture of childhood ALL on disease persistence. Also, the impact of the leukemic niche on residual leukemia cells in the bone marrow and extramedullary compartments is reviewed. We further discuss existing in vivo models of minimal residual disease based on different cellular labelling strategies and engraftment of ALL cells in immunodeficient mouse strains. We finally draw some conclusions on potential strategies targeting residual ALL cells, with a focus on cellular and antibodybased immunotherapy.
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0.546
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Publication type
Article: Journal article
Document type
Review
Keywords
Acute Lymphoblastic Leukemia ; Childhood Leukemia ; B-cell Precursor ; Mrd ; Dormancy ; Mesenchymal Stem Cells ; Quiescent Cells ; Xenograft Models ; Immunodeficient Mice; Central-nervous-system; Relapse-free Survival; Car T-cells; Propagating Cells; Genomic Landscape; Cns Infiltration; Stem-cells; Aieop-bfm; B-all; Precursor
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
0065-2598
Quellenangaben
Volume: 1100,
Pages: 127-139
Publisher
Springer
Publishing Place
New York
Reviewing status
Peer reviewed
Institute(s)
Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-506600-001
WOS ID
WOS:000457972100009
Scopus ID
85056431726
PubMed ID
30411264
Erfassungsdatum
2018-12-05