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Open Access Green as soon as Postprint is submitted to ZB.
Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia.
Adv. Exp. Med. Biol. 1100, 127-139 (2018)
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Early response to therapy, especially the measurement of minimal residual disease (MRD), remains the most reliable and strongest independent prognostic parameter. Intriguingly, little is known on the mechanisms sustaining MRD in that disease. Here, we summarize existing evidence on the influences of molecular genetics and clonal architecture of childhood ALL on disease persistence. Also, the impact of the leukemic niche on residual leukemia cells in the bone marrow and extramedullary compartments is reviewed. We further discuss existing in vivo models of minimal residual disease based on different cellular labelling strategies and engraftment of ALL cells in immunodeficient mouse strains. We finally draw some conclusions on potential strategies targeting residual ALL cells, with a focus on cellular and antibodybased immunotherapy.
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Publication type
Article: Journal article
Document type
Review
Keywords
Acute Lymphoblastic Leukemia ; Childhood Leukemia ; B-cell Precursor ; Mrd ; Dormancy ; Mesenchymal Stem Cells ; Quiescent Cells ; Xenograft Models ; Immunodeficient Mice; Central-nervous-system; Relapse-free Survival; Car T-cells; Propagating Cells; Genomic Landscape; Cns Infiltration; Stem-cells; Aieop-bfm; B-all; Precursor
ISSN (print) / ISBN
0065-2598
Quellenangaben
Volume: 1100,
Pages: 127-139
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)