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Brokhman, I.* ; Xu, J.* ; Coles, B.L.K.* ; Razavi, R.* ; Engert, S. ; Lickert, H. ; Babona-Pilipos, R.* ; Morshead, C.M.* ; Sibley, E.* ; Chen, C.* ; van der Kooy, D.*

Dual embryonic origin of the mammalian enteric nervous system.

Dev. Biol. 445, 256-270 (2019)
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The enteric nervous system is thought to originate solely from the neural crest. Transgenic lineage tracing revealed a novel population of clonal pancreatic duodenal homeobox-1 (Pdx1)-Cre lineage progenitor cells in the tunica muscularis of the gut that produced pancreatic descendants as well as neurons upon differentiation in vitro. Additionally, an in vivo subpopulation of endoderm lineage enteric neurons, but not glial cells, was seen especially in the proximal gut. Analysis of early transgenic embryos revealed Pdx1-Cre progeny (as well as Sox-17-Cre and Foxa2-Cre progeny) migrating from the developing pancreas and duodenum at E11.5 and contributing to the enteric nervous system. These results show that the mammalian enteric nervous system arises from both the neural crest and the endoderm. Moreover, in adult mice there are separate Wnt1-Cre neural crest stem cells and Pdx1-Cre pancreatic progenitors within the muscle layer of the gut.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Duodenum ; Enteric Nervous System ; Lineage Tracing ; Neural Crest ; Pancreas ; Pdx1-cre-derived Neural Progenitors
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0012-1606
e-ISSN 0012-1606
Journal Developmental Biology
Quellenangaben Volume: 445, Issue: 2, Pages: 256-270 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-231
G-502300-001
DOI 10.1016/j.ydbio.2018.11.014
Scopus ID 85057292643
PubMed ID 30472119
Erfassungsdatum 2018-12-05
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