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    Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.
        
        Curr. Opin. Microbiol. 46, 116-122 (2018)
    
    
    
	    Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
	
	
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        Publication type
        Article: Journal article
    
 
    
        Document type
        Review
    
 
     
    
    
        Keywords
        Trypanosoma-brucei; Functional-characterization; Receptors Pex5; Compartmentation; Identification; Recognition; Glycolysis; Phosphofructokinase; Hexokinase; Inhibitors
    
 
     
    
    
        Language
        
    
 
    
        Publication Year
        2018
    
 
     
    
        HGF-reported in Year
        2018
    
 
    
    
        ISSN (print) / ISBN
        1369-5274
    
 
    
        e-ISSN
        1879-0364
    
 
    
     
     
	     
	 
	 
    
        Journal
        Current opinion in microbiology
    
 
	
    
        Quellenangaben
        
	    Volume: 46,  
	    
	    Pages: 116-122 
	    
	    
	
    
 
    
         
        
            Publisher
            Current Biology Ltd.
        
 
        
            Publishing Place
            London
        
 
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Reviewing status
        Peer reviewed
    
 
    
        Institute(s)
        Institute of Structural Biology (STB)
    
 
    
        POF-Topic(s)
        30203 - Molecular Targets and Therapies
    
 
    
        Research field(s)
        Enabling and Novel Technologies
    
 
    
        PSP Element(s)
        G-503000-001
    
 
     
     	
    
    
        WOS ID
        WOS:000454967500019
    
    
        Scopus ID
        85057078424
    
    
        PubMed ID
        30481613
    
    
        Erfassungsdatum
        2018-12-12