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Kalel, V.C.* ; Mäser, P.* ; Sattler, M. ; Erdmann, R.* ; Popowicz, G.M.

Come, sweet death: Targeting glycosomal protein import for antitrypanosomal drug development.

Curr. Opin. Microbiol. 46, 116-122 (2018)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
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Publication type Article: Journal article
Document type Review
Keywords Trypanosoma-brucei; Functional-characterization; Receptors Pex5; Compartmentation; Identification; Recognition; Glycolysis; Phosphofructokinase; Hexokinase; Inhibitors
Language
Publication Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1369-5274
e-ISSN 1879-0364
Quellenangaben Volume: 46, Issue: , Pages: 116-122 Article Number: , Supplement: ,
Publisher Current Biology Ltd.
Publishing Place London
Reviewing status Peer reviewed
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503000-001
Scopus ID 85057078424
PubMed ID 30481613
Erfassungsdatum 2018-12-12