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Ruepp, A. ; Doudieu, O.N. ; van den Oever, J. ; Brauner, B. ; Dunger-Kaltenbach, I. ; Fobo, G. ; Frishman, G. ; Montrone, C. ; Skornia, C. ; Wanka, S. ; Rattei, T.* ; Pagel, P. ; Riley, M.L. ; Frishman, D.* ; Surmeli, D. ; Tetko, I.V. ; Oesterheld, M. ; Stuempflen, V. ; Mewes, H.-W.

The mouse functional genome database (MfunGD) :Functional annotation of proteins in the light of their cellular context.

Nucleic Acids Res. 34, D568–D571 (2006)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords WHOLE GENOMES; NETWORK; RESOURCE; MOTIFS; MIPS
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Journal Nucleic Acids Research
Quellenangaben Volume: 34, Issue: SI, Pages: D568–D571 Article Number: , Supplement: ,
Publisher Oxford University Press
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)