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The DIMA web resource-exploring the protein domain network.
Bioinformatics 22, 997-998 (2006)
Conserved domains represent essential building blocks of most known proteins. Owing to their role as modular components carrying out specific functions they form a network based both on functional relations and direct physical interactions. We have previously shown that domain interaction networks provide substantially novel information with respect to networks built on full-length protein chains. In this work we present a comprehensive web resource for exploring the Domain Interaction MAp (DIMA), interactively. The tool aims at integration of multiple data sources and prediction techniques, two of which have been implemented so far: domain phylogenetic profiling and experimentally demonstrated domain contacts from known three-dimensional structures. A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
DATABASE
e-ISSN
1367-4811
Journal
Bioinformatics
Quellenangaben
Volume: 22,
Issue: 8,
Pages: 997-998
Publisher
Oxford University Press
Publishing Place
Oxford
Reviewing status
Peer reviewed