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Immunometabolic crosstalk: An ancestral principle of trained immunity?
Trends Immunol. 40, 1-11 (2019)
Memory was traditionally considered an exclusive hallmark of adaptive immunity. This dogma was challenged by recent reports that myeloid cells can retain 'memory' of earlier challenges, enabling them to respond strongly to a secondary stimulus. This process, designated 'trained immunity', is initiated by modulation of precursors of myeloid cells in the bone marrow. The ancestral innate immune system of lower organisms (e.g., Caenorhabditis elegans) can build long-lasting memory that modifies responses to secondary pathogen encounters. We posit that changes in cellular metabolism may be a common denominator of innate immune memory from lower animals to mammals. We discuss evidence from C. elegans and murine/human systems supporting the concept of an ancestral principle regulating innate immune memory by controlling cellular metabolism.
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Publication type
Article: Journal article
Document type
Review
Keywords
Hematopoietic Stem-cells; Elegans Life-span; Innate Immunity; Caenorhabditis-elegans; Clonal Hematopoiesis; C. Elegans; Tissue Macrophages; Energy-metabolism; Molecular-basis; Infection
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Journal
Trends in Immunology
Quellenangaben
Volume: 40,
Issue: 1,
Pages: 1-11
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)