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Four-dimensional optoacoustic monitoring of tissue heating with medium intensity focused ultrasound.
Ultrasonics 94, 117-123 (2018)
Medium-intensity focused ultrasound (MIFU) concerns therapeutic ultrasound interventions aimed at stimulating physiological mechanisms to reinforce healing responses without reaching temperatures that can cause permanent tissue damage. The therapeutic outcome is strongly affected by the temperature distribution in the treated region and its accurate monitoring represents an unmet clinical need. In this work, we investigate on the capacities of four-dimensional optoacoustic tomography to monitor tissue heating with MIFU. Calibration experiments in a tissue-mimicking phantom have confirmed that the optoacoustically-estimated temperature variations accurately match the simultaneously acquired thermocouple readings. The performance of the suggested approach in real tissues was further shown with bovine muscle samples. Volumetric temperature maps were rendered in real time, allowing for dynamic monitoring of the ultrasound focal region, estimation of the peak temperature and the size of the heat-affected volume.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Thermal Treatment Monitoring ; Optoacoustic Tomography ; Photoacoustic Imaging ; Temperature Monitoring ; Therapeutic Ultrasound; Real-time; Therapeutic Ultrasound; Soft-tissue; Thermometry; Ablation
ISSN (print) / ISBN
0041-624x
e-ISSN
1874-9968
Journal
Ultrasonics
Quellenangaben
Volume: 94,
Pages: 117-123
Publisher
Elsevier
Publishing Place
Amsterdam [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)