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García-Cáceres, C. ; Balland, E.* ; Prévot, V.* ; Luquet, S.* ; Woods, S.C.* ; Koch, M.* ; Horvath, T.L.* ; Yi, C.X.* ; Chowen, J.A.* ; Verkhratsky, A.* ; Araque, A.* ; Bechmann, I.* ; Tschöp, M.H.

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.

Nat. Neurosci. 22, 7-14 (2019)
Postprint DOI PMC
Open Access Green
Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic feeding circuits. These non-neuronal cells are crucial in determining the functional interactions of specific neuronal subpopulations involved in the control of metabolism. Recent advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuronal-glial networks. Here we summarize the progress in the field and argue that glial-neuronal interactions provide a core hub integrating food-related cues, interoceptive signals, and internal states to adapt a complex set of physiological responses operating on different timescales to finely tune behavior and metabolism according to metabolic status. This expanding knowledge helps to redefine our understanding of the physiology of food intake and energy metabolism.
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Publication type Article: Journal article
Document type Review
Keywords Gomori-positive Astrocytes; Beta/nf-kappa-b; Agrp-neurons; Body-weight; Food-intake; Arcuate Nucleus; Pomc Neurons; Hypocretin Orexin; Neural Circuits; Neuropeptide-y
Language
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Journal Nature Neuroscience
Quellenangaben Volume: 22, Issue: 1, Pages: 7-14 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place 75 Varick St, 9th Flr, New York, Ny 10013-1917 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502200-001
G-501900-221
DOI 10.1038/s41593-018-0286-y
WOS ID WOS:000453388700004
Scopus ID 85058169554
PubMed ID 30531847
Erfassungsdatum 2018-12-13
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