PuSH - Publication Server of Helmholtz Zentrum München: Arsenic and arsenic compounds – Determination of arsenic species (As(III), As(V), monomethylarsonic acid, dimethylarsinic acid and arsenobetaine) in urine by HPLC‐ICP‐MS [Biomonitoring Methods, 2018].

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Schramel, P. ; Michalke, B. ; Emons, H.* ; Göen, T.* ; Hartwig, A.*

Arsenic and arsenic compounds – Determination of arsenic species (As(III), As(V), monomethylarsonic acid, dimethylarsinic acid and arsenobetaine) in urine by HPLC‐ICP‐MS [Biomonitoring Methods, 2018].

Arsen und Arsenverbindungen – Bestimmung von Arsenspezies (As(III), As(V), Monomethylarsonsäure, Dimethylarsinsäure und Arsenobetain) in Urin mittels HPLC‐ICP‐MS [Biomonitoring Methods in German language, 2018].

MAK Coll. Occup. Health Saf. 3, 2186-2207 (2018)

DOI

Abstract
Metrics
Extra information

The working group “Analyses in Biological Materials” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The analytical method described hereinafter permits the simple and specific determination of the arsenic species arsenic (III) (As³⁺), arsenic (V) (As⁵⁺), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and arsenobetaine in urine. The limits of quantitation allow the quantification of the above‐mentioned arsenic species in both occupational and environmental medicine. To this end, the arsenic species are separated by anion‐exchange high‐performance liquid chromatography (anion‐exchange HPLC) and detected by inductively coupled plasma mass spectrometry (ICP‐MS). Sample preparation is done by diluting the urine with water. Calibration is performed using either single or mixed standards of the different arsenic species or using the standard addition method. The method was extensively validated and the reliability data were confirmed by an independent laboratory, which has established and cross‐checked the whole procedure.

Die hier beschriebene analytische Methode erlaubt die einfache und spezifische Bestimmung der Arsenspezies Arsen(III) (As³⁺), Arsen(V) (As⁵⁺), Monomethylarsonsäure (MMA), Dimethylarsinsäure (DMA) und Arsenobetain im Urin. Die Bestimmungsgrenzen erlauben die Quantifizierung der genannten Arsenspezies sowohl im arbeitsmedizinischen als auch im umweltmedizinischen Bereich. Dazu werden die Arsenspezies mittels Anionenaustausch‐Hochleistungsflüssigkeitschromatographie (Anionenaustausch‐HPLC) getrennt und mittels Massenspektrometrie mit induktiv gekoppeltem Plasma (ICP‐MS) bestimmt. Die Probenvorbereitung erfolgt durch Verdünnung des Urins mit Wasser. Die Kalibrierung erfolgt entweder mit Einzel‐ bzw. Mischstandards der verschiedenen Arsenspezies oder unter Verwendung der Standardadditionsmethode.

Impact Factor

Scopus SNIP

Altmetric

0.000