PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Meyer, J.* ; Eley, J.* ; Schmid, T.E. ; Combs, S.E. ; Dendale, R.* ; Prezado, Y.*

Spatially fractionated proton minibeams.

Br. J. Radiol. 91:20180466 (2019)
Publ. Version/Full Text DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
Extraordinary normal tissue response to highly spatially fractionated X-ray beams has been explored for over 25 years. More recently, alternative radiation sources have been developed and utilized with the aim to evoke comparable effects. These include protons, which lend themselves well for this endeavour due to their physical depth dose characteristics as well as corresponding variable biological effectiveness. This paper addresses the motivation for using protons to generate spatially fractionated beams and reviews the technological implementations and experimental results to date. This includes simulation and feasibility studies, collimation and beam characteristics, dosimetry and biological considerations as well as the results of in vivo and in vitro studies. Experimental results are emerging indicating an extraordinary normal tissue sparing effect analogous to what has been observed for synchrotron generated X-ray microbeams. The potential for translational research and feasibility of spatially modulated proton beams in clinical settings is discussed.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
1.939
0.928
14
16
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Review
Keywords Equivalent Uniform Dose ; Microbeam Radiotherapy ; Normal Tissue Sparing ; Relative Biological Effectiveness ; Spatially Fractionated Radiation Therapy; Microbeam Radiation-therapy; Glioma-bearing Rats; Microplanar Beams; 9l Gliosarcoma; Spinal-cord; Synchrotron; Brain; Radiotherapy; Irradiation; Skin
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 0007-1285
e-ISSN 1748-880X
Journal British Journal of Radiology, The
Quellenangaben Volume: 91, Issue: 1095, Pages: , Article Number: 20180466 Supplement: ,
Publisher British Institute of Radiology N.S
Publishing Place 36 Portland Place, London W1n 4at, England
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
DOI 10.1259/bjr.20180466
WOS ID WOS:000459432000013
Scopus ID 85061991257
PubMed ID 30359081
Erfassungsdatum 2018-12-13
[➜Report correction]