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Open Access Green as soon as Postprint is submitted to ZB.
Innate immune cells in the adipose tissue.
Rev. Endocr. Metab. Disord. 19, 283-292 (2018)
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adipose Tissue ; Inflammation ; Obesity ; Innate Immunity ; Macrophages ; Eosinophils ; Innate Lymphoid Cells; Alternatively Activated Macrophages; Plasmacytoid Dendritic Cells; Obesity-induced Inflammation; Natural-killer-cells; Diet-induced Obesity; Insulin-resistance; Neutrophil Elastase; Energy-expenditure; Lymphoid Type-2; Visceral Fat
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
1389-9155
e-ISSN
1573-2606
Quellenangaben
Volume: 19,
Issue: 4,
Pages: 283-292
Publisher
Springer
Publishing Place
Boston
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502600-008
WOS ID
WOS:000458187800002
PubMed ID
29922964
Erfassungsdatum
2018-12-20