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von Loeffelholz, C.* ; Gissey, L.C.* ; Schumann, T.* ; Henke, C.* ; Kurzbach, A.* ; Struck, J.* ; Bergmann, A.* ; Hanefeld, M.* ; Schatz, U.* ; Bornstein, S.R. ; Casella, G.* ; Mingrone, G.* ; Birkenfeld, A.L.

The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery.

Int. J. Obes. 42, 2057-2061 (2018)
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Neurotensin is a peptide with effects on appetite and intestinal lipid absorption. Experimental data suggest a role in glucose homeostasis, while human data is missing. Here, 20 morbidly obese subjects either underwent biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB) in a randomized fashion. Before and 1 year after surgery, anthropometric data, body composition, clinical biochemistry, insulin sensitivity by means of euglycemic hyperinsulinemic clamps (HEC) and fasting plasma proneurotensin 1-117 were analyzed. Plasma proneurotensin increased significantly more 1 year after BDP than RYGB (P = 0.028), while weight loss was comparable. After metabolic surgery, proneurotensin correlated positively with insulin sensitivity (M-value) (r = 0.55, P < 0.001), while an inverse relationship with fasting glucose, HOMA-IR and HbA1c was observed (P < 0.05 for all components). After adjustment for age and gender, proneurotensin and BMI remained independently related with delta of M-value (beta = 0.46 and beta = 0.51, P < 0.05, resp.). From these data we conclude that proneurotensin positively correlates with insulin sensitivity uniquely after weight loss induced by metabolic surgery in humans. BDP leads to a stronger increase in the anorexigenic peptide compared to RYGB.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gastric Bypass; Cardiovascular-disease; Proneurotensin; Resistance
ISSN (print) / ISBN 0307-0565
e-ISSN 1476-5497
Journal International Journal of Obesity
Quellenangaben Volume: 42, Issue: 12, Pages: 2057-2061 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Macmillan Building, 4 Crinan St, London N1 9xw, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute for Pancreatic Beta Cell Research (IPI)