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Brede, S.* ; Fehr, S.* ; Dalla-Man, C.* ; Cobelli, C.* ; Lehnert, H.* ; Hallschmid, M. ; Klement, J.*

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men.

Diabetes Obes. Metab. 21, 424-428 (2019)
Postprint DOI PMC
Open Access Green
The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta-cell responsivity and glucose tolerance in normal-weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen obese healthy men with an average body mass index of 35 kg/m(2) and an average body fat content of 33% received a single intranasal dose (24 IU) of oxytocin before undergoing an oral glucose tolerance test. Results were analysed according to the oral minimal model and compared with our findings in normal-weight participants. In contrast to the results in normal-weight subjects, oxytocin did not blunt postprandial glucose and insulin excursions in obese men, and moreover failed to enhance beta-cell responsivity and glucose tolerance. These results indicate that pronounced obesity may be associated with a certain degree of resistance to the glucoregulatory impact of exogenous oxytocin, and underlines the need for further investigations into the potential of oxytocin to improve glucose homeostasis in the clinical context.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Beta Cell Function ; Body Composition ; Clinical Physiology ; Endocrine Therapy ; Glucose Metabolism ; Neuropharmacology; Food-intake
ISSN (print) / ISBN 1462-8902
e-ISSN 1463-1326
Journal Diabetes, Obesity and Metabolism
Quellenangaben Volume: 21, Issue: 2, Pages: 424-428 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)