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Chip-based heat stimulation for modulating signal propagation in HL-1 cell networks.
Adv. Biosyst. 2:1800138 (2018)
Signal propagation in cardiac cell networks can be modulated by heat stimulation. Here, the response of a connected HL-1 cardiomyocyte cell network to the application of confined heat stimuli using Ca 2+ imaging is investigated. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. It is demonstrated that upon heat stimulation, the velocity of the propagating Ca 2+ wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell is shown. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Ca Signal Propagation 2+ ; Cardiomyocytes ; Cells-on-chip ; Heat Stimulation
Language
english
Publication Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
2366-7478
e-ISSN
2366-7478
Journal
Advanced biosystems
Quellenangaben
Volume: 2,
Issue: 12,
Article Number: 1800138
Publisher
Wiley
Publishing Place
Weinheim
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30505 - New Technologies for Biomedical Discoveries
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-552000-001
Scopus ID
85065054508
Erfassungsdatum
2018-12-21