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Glucose-regulated TET2 activity links cancer to diabetes.
Trends Cancer 5, 5-7 (2019)
Diabetes has long been associated with an increased risk of cancer. While many molecular connections likely exist between the diseases, a recent publication discovered a clear molecular link, demonstrating that a glucose-dependent destabilisation of the DNA demethylase TET2 can promote-malignant transformation via an AMPK-dependent phosphoswitch.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Dna Methylation
ISSN (print) / ISBN
2405-8033
e-ISSN
2405-8025
Journal
Trends in cancer
Quellenangaben
Volume: 5,
Issue: 1,
Pages: 5-7
Publisher
Elsevier
Publishing Place
Amsterdam
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)