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Glucose-regulated TET2 activity links cancer to diabetes.
Trends Cancer 5, 5-7 (2019)
Diabetes has long been associated with an increased risk of cancer. While many molecular connections likely exist between the diseases, a recent publication discovered a clear molecular link, demonstrating that a glucose-dependent destabilisation of the DNA demethylase TET2 can promote-malignant transformation via an AMPK-dependent phosphoswitch.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Dna Methylation
Language
english
Publication Year
2019
Prepublished in Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
2405-8033
e-ISSN
2405-8025
Journal
Trends in cancer
Quellenangaben
Volume: 5,
Issue: 1,
Pages: 5-7
Publisher
Elsevier
Publishing Place
Amsterdam
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
WOS ID
WOS:000454998700002
PubMed ID
30616756
Erfassungsdatum
2019-01-21