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High resolution volumetric imaging of primary and secondary tumor spheroids using multi-angle Light Sheet Fluorescence Microscopy (LSFM).
Conf. Proc. IEEE Eng. Med. Biol. Soc. 2018, 866-869 (2018)
Breast cancer and Glioblastoma brain cancer are severe malignancies with poor prognosis. In this study, primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. High resolution imaging of both primary and secondary cancer cell spheroids is possible using a custom multi-angle Light Sheet Fluorescence Microscope. Such a technique is successful in realizing preclinical drug screening, while enables the discrimination among physiologic tumor parameters.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1557-170X
Conference Title
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Conference Date
18-21 July 2018
Conference Location
Hawaii, Honolulu
Quellenangaben
Volume: 2018,
Pages: 866-869
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)