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Hübner, J.* ; Lewin, P.* ; Pritzkuleit, R.* ; Eisemann, N.* ; Maier, W. ; Katalinic, A.*

Colorectal cancer screening by colonoscopy and trends in disease-specific mortality: A population-based ecological study of 358 German districts.

Int. J. Colorectal Dis. 34, 599-605 (2019)
DOI PMC
Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Purpose Screening for colorectal cancer (CRC) by colonoscopy was implemented in Germany in 2002. Although the procedure has proven to be effective in reducing disease-specific mortality in numerous clinical studies, its effect at the population level is unclear. We performed an ecological study at the level of 358 German districts, testing the hypothesis that a higher participation rate in screening colonoscopy is associated with a stronger decline in CRC mortality from 2001 to 2012.Methods Information on the use of colonoscopy in each district was extracted from settlement data, used for the remuneration of physicians of the ambulant sector from 2008 to 2011. Yearly mortality rates for each district from 2001 to 2012 were derived from the official mortality statistics. A spatial model was fitted, considering other factors which might influence early detection of CRC (fecal occult blood test (FOBT), diagnostic colonoscopy, material and social area deprivation, and rural-urban disparities).Results The population-weighted mean annual participation rate during 2008-2011 in screening colonoscopy was 2.0% (range 0.6 to 3.9%). The weighted mean annual percentage change (APC) of CRC mortality was -2.9% (range -7.8 to 1.2%). According to the fully adjusted model, a 1% higher annual participation rate in colonoscopy screening was associated with an additional annual change in CRC mortality rate of -0.34% (p = 0.015). Given an annual 2.0% participation rate, colonoscopy screening attributed 23% to the observed decline.Conclusions Our real-world data from Germany provide first evidence that colonoscopy screening for CRC is effective in reducing disease-specific mortality at the population level.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Colorectal Cancer ; Screening ; Colonoscopy ; Mortality ; Epidemiology
ISSN (print) / ISBN 0179-1958
e-ISSN 1432-1262
Journal International Journal of Colorectal Disease
Quellenangaben Volume: 34, Issue: 4, Pages: 599-605 Article Number: , Supplement: ,
Publisher Springer
Publishing Place 233 Spring St, New York, Ny 10013 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)