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Wei, H.* ; Bruns, O.T. ; Kaul, M.G.* ; Hansen, E.C.* ; Barch, M.* ; Wiśniowska, A.* ; Chen, O.* ; Chen, Y.* ; Li, N.* ; Okada, S.* ; Cordero, J.M.* ; Heine, M.* ; Farrar, C.T.* ; Montana, D.M.* ; Adam, G.* ; Ittrich, H.* ; Jasanoff, A.* ; Nielsen, P.* ; Bawendi, M.G.*

Exceedingly small iron oxide nanoparticles as positive MRI contrast agents.

Proc. Natl. Acad. Sci. U.S.A. 114, 2325-2330 (2017)
DOI PMC
Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. GBCAs have shown efficacy and are safe to use with most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd) exposure during MRI with contrast. In addition, Gd deposition in the human brain has been reported following contrast, and this is now under investigation by the US Food and Drug Administration (FDA). To address a perceived need for a Gd-free contrast agent with pharmacokinetic and imaging properties comparable to GBCAs, we have designed and developed zwitterion-coated exceedingly small superparamagnetic iron oxide nanoparticles (ZES-SPIONs) consisting of ∼3-nm inorganic cores and ∼1-nm ultrathin hydrophilic shell. These ZES-SPIONs are free of Gd and show a high T contrast power. We demonstrate the potential of ZES-SPIONs in preclinical MRI and magnetic resonance angiography.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Exceedingly Small Iron Oxide Nanoparticles ; Gadolinium-free Positive Mr Contrast Agent ; Preclinical Magnetic Resonance Imaging ; Renal Clearance
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 114, Issue: 9, Pages: 2325-2330 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)