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Open Access Green as soon as Postprint is submitted to ZB.
Flavylium polymethine fluorophores for near- and shortwave infrared imaging.
Angew. Chem.-Int. Edit. 56, 13126-13129 (2017)
Bright fluorophores in the near-infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging in vivo. In this work, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission wavelengths from 680 to 1045 nm. Photophysical characterization revealed that the 1- and 3-methine dyes display enhanced photostability and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7-methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR in vivo imaging.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Fluorescent Dyes ; Imaging Agents ; Near-infrared ; Polymethines ; Shortwave Infrared
ISSN (print) / ISBN
1433-7851
e-ISSN
1521-3773
Quellenangaben
Volume: 56,
Issue: 42,
Pages: 13126-13129
Publisher
Wiley
Publishing Place
Weinheim
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)