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Open Access Green as soon as Postprint is submitted to ZB.
Shortwave infrared in vivo imaging with gold nanoclusters.
Nano Lett. 17, 6330-6334 (2017)
The use of visible/NIR-emitting gold nanoclusters (Au NCs), previously proposed for in vivo imaging, has been limited to some extent by low quantum yields (QYs) and the limited penetration of visible light in tissue. Here we report short wavelength infrared (SWIR, λ = 1-2 μm) emitting Au NCs with a good photoluminescence QY for this wavelength range (0.6% to 3.8% for λ = 1000 to 900 nm) and excellent stability under physiological conditions. We show that surface ligand chemistry is critical to achieving these properties. We demonstrate the potential of these SWIR-emitting Au NCs for in vivo imaging in mice. The Au NCs have a hydrodynamic diameter that is small (∼5 nm) enough that they exhibit a rapid renal clearance, and images taken in the SWIR region show better resolution of the blood vessels than in the NIR region.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Gold Nanocluster ; Swir Imaging ; Renal Clearance ; Zwitterionic Ligand
ISSN (print) / ISBN
1530-6984
e-ISSN
1530-6992
Journal
Nano Letters
Quellenangaben
Volume: 17,
Issue: 10,
Pages: 6330-6334
Publisher
American Chemical Society (ACS)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)